∞ generated and posted on 2022.07.07 ∞
Calculation of extent of bacterial reduction after some defined span of time and allowing for in situ phage population growth over that time span.
Please cite as:
Stephen T. Abedon
Active Phage Therapy Calculator.
active.phage-therapy.org
Click here for calculator or see immediately below for further explanation and discussion.
| This calculator simulates phage-bacterial community dynamics, providing various end-point values such as phage and bacterial concentrations, comparing these to starting values The underlying simulations are incremented in intervals of 1 min, can include or not include free phage inactivation for reasons other than phage adsorption to bacteria, can include bacterial replication (as controlled by the Malthusian parameter), and can be varied in terms of starting phage titers, starting bacterial concentrations, duration of simulations, phage adsorption rate constant, phage latent period, and phage burst size. MOIinput (MOI input) is defined as the ratio of phages added to phage-targeted bacteria. See the following for discussion of modeling phage-bacterial community dynamics: Stopar, D., Abedon, S. T. (2008). Modeling bacteriophage population growth. In: Bacteriophage Ecology, Abedon, S. T. (ed), Cambridge University Press, Cambridge. pp. 389-414. Abedon, S. T. (2009). Deconstructing chemostats towards greater phage-modeling precision. In: Contemporary Trends in Bacteriophage Research, Adams, H. T. (ed), Nova Science Publishers, Hauppauge, New York. pp. 249-283. For an open access discussion, see |