∞ generated and posted on 2023.09.07 ∞
How many phages on average are expected to adsorb over some interval of time for a given starting phage titer?
Please cite as:
Stephen T. Abedon
Phage Adsorptions Calculator.
adsorptions.phage-therapy.org
Click here for calculator or see immediately below for further explanation and discussion.
| Adsorption rates are easy to calculate once one has knowledge of phage titers and phage adsorption rate constants as well as, though not always as relevant, bacterial concentrations. Here a variety of calculations are solved including expected total number of adsorptions, expected average number of adsorptions per bacterium, and expected average number of adsorptions per bacterium per unit time. Calculations are made both assuming (less realistic) and not assuming (more realistic) phage virion replacement upon adsorption. The former is simpler but tends to be less accurate particularly given higher bacterial concentrations or longer durations over which adsorptions occur. -------------------------------------- For further discussion, see: Abedon, S.T. (2011). Phage Therapy Pharmacology: Calculating Phage Dosing. Advances in Applied Microbiology 77:1-40. Abedon, S.T. (2023). Bacteriophage Adsorption: Likelihood of Virion Encounter with Bacteria and Other Factors Affecting Rates. Antibiotics 12:723. See also the Bacterial Half-Life Calculator, Decimal Reduction Time Phage Therapy Calculator, and the Inundative Phage Density Calculator. |